Cyclin D1: A Golden Gene in Cancer, Cardiotoxicity, and Cardioprotection

Objective: Cyclin D1 is an essential protein that acts as a mitogenic sensor. In this manuscript, we discuss the importance of cyclin in oncology and cardio-oncology, challenge prognostic therapeutic response values to figure out if it can be beneficial marker. We also agents microRNAs used potential approach via regulating expression cardio-oncology. Discussion: Clinical significance defined not only several cancers such breast cancer, melanoma, glioblastoma but cardiomyocyte regeneration cardiac hypertrophic growth. Several studies have indicated injection cardiotoxic doxorubicin (DOX) induces damage system increases D at single injection, which might related DXO-mediated adult heart. However, overexpression leads growth cardiomyocytes, cyclin-dependent kinase (CDK)) inhibitors p16 do inhibit cardiomyocytes. Thus, reaction CDK-independent. Conclusions: positively correlated with tumor progression, treatment response, cardiotoxicity, poor prognosis. has important role hypertrophy, promising marker monitoring responses, cardioprotection, cardiotoxicity. Finally, plays cardiomyocytes novel mechanism. Given all these pieces evidence, introduced favorable biomarker future cardiology